A substance that when administered to a recipient can elicit a change in the state of the immune system. It can be a change from sensitization to tolerance in allergic disease of from naivete or tolerance to protective sensitization against infectious agents or against the tumor-specific antigens of cancers.

An antigen for which the range of known responses includes allergic sensitization.

If one injects pre-formed particles in the 0.5-to-5-micron size range for efficient APC uptake they will stay in clumps where APCs cannot reach them. ADBP is the method discovered by Dr. Coifman to create particles in this size range where APCs can find and reach them by precipitation. Read more: https://bomepharma.com/immunotherapy/ https://pubs.acs.org/doi/10.1021/bc800317a

A process of administering an allergen to which the recipient is allergic in a manner designed to safely induce tolerance to that allergen. Read more: https://pmc.ncbi.nlm.nih.gov/articles/PMC9575636/

An allergic reaction that typically presents as allergic eczema. A common example The rash induced by allergy to poison ivy is. Read more: https://www.ncbi.nlm.nih.gov/books/NBK459230/

The five main isotypes of immunoglobulin are IgM, IgD, IgG, IgE, and IgA. IgE is the antibody isotype that mediates most reactions to environmental allergens and foods. Read more: https://www.ncbi.nlm.nih.gov/books/NBK27106/

Cells that migrate through body tissues picking up samples of things that might not belong, delivering them to lymph nodes for processing by the immune system. APCs pick up particles in the 0.5-to-5-micron size range with particularly high efficiency. Read more: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/antigen-presenting-cell

Cancers exist when the patient’s immune system has not recognized or developed protective sensitization to the cell surface changes that make cancer cells cancerous. The field of cancer immunotherapy encompasses a diverse range of strategies directed at the achievement of this therapeutic goal. ADBP and others incorporate therapeutic administration of the antigens to which the patient’s pre-treatment response was insufficient. Read more: https://www.cancer.gov/about-cancer/treatment/types/immunotherapy

Chronic infectious diseases are illnesses caused by viruses, bacteria, or other infectious agents to which the patient has been for enough time to have developed a protective immune response but has not done so. Immunotherapy for chronic infectious diseases, such as TB and malaria, is the field of efforts to safely induce those responses. Read more: https://www.ncbi.nlm.nih.gov/books/NBK8538/